Lithium toxicity antidote7/5/2023 ![]() ![]() This inhibition, in turn, affects neurotransmission through the phosphatidylinositol secondary messenger system. It may alter intracellular signaling via second messenger systems by inhibition of inositol monophosphate. It alters the metabolism of neurotransmitters, specifically catecholamines and serotonin. Lithium modifies sodium transport in nerve and muscle cells. It is rapidly absorbed, has a small volume of distribution, and is excreted in the urine unchanged (there is no metabolism of lithium). The mechanism of action of lithium is not known. Patients with rapid cycling and mixed state types of bipolar disorder generally do less well on lithium. These are off-label uses, meaning they are not FDA-approved. Lithium is also prescribed for major depressive disorder as an adjunct therapy, bipolar disorder without a history of mania, treatment of vascular headaches, and neutropenia. The primary target symptoms of lithium are mania and unstable mood. ![]() Lithium was the first mood stabilizer and is still the first-line treatment option, but is underutilized because it is an older drug. Lithium is a commonly prescribed drug for a manic episode in bipolar disorder as well as maintenance therapy of bipolar disorder in a patient with a history of a manic episode. Review the importance of a well-coordinated interprofessional team in caring for patients undergoing lithium therapy.Explain the need for monitoring lithium levels.Describe the potential adverse effects of lithium therapy.Identify the indications for lithium therapy.This activity highlights the role of the interprofessional team in caring for patients who are undergoing, or who may undergo lithium therapy. This activity outlines the indications and contraindications for lithium use, provides instructions for administration and monitoring, and reviews lithium toxicity. It is often underutilized because of the potential for side effects, and perhaps because it is an older drug. Despite the availability of newer mood stabilizers, lithium continues to be a first-line treatment for bipolar disorder. ![]()
0 Comments
Leave a Reply. |